DocVal’s notes on Pharmaceutical Hormones
Gynecologists generally give synthetic estrogens and progestins (Provera / Premarin) to their patients to treat menopausal symptoms and menstrual irregularities; these monster drugs are extremely dangerous. We shouldn’t fault the doctor; that’s how they were trained; however we can fault the Drug manufacturers. They do know better and actually have been sweeping the facts under the rug for many decades.
It has become quite clear to the more informed Doctors that these symptomatic women rarely need estrogen at all and certainly not in the massive overdose even the “low dose” pill delivers.
Estrogen only drops 10-30% in post menopausal women, even less in American Women because fat cells make estrogen.
Progesterone on the other hand does drop considerably and it is the resulting imbalance between the relatively normal estrogen level and the lowering progesterone that causes the dreaded female problems...
Pharmaceutical Estrogens when taken orally cause thrombosis, stroke and breast cancer; bio-identical estrogens do not. Bio-identical estrogen is absorbed through the skin and enters the blood “naturally”, similar to the way our natural estrogens are released into the blood from the ovary. There is nothing natural about the patented drugs; in fact they are so unnatural they can be patented. Any substance that is normally found in the body cannot be patented.
It’s all about balance; balance between estrogen, progesterone and the other hormones. We test, measure what is lacking, and gently but naturally, replace what is missing with the identical substance your body normally would make if it weren’t weakened from years of stress.
The truth about Premarin;
Wyeth in 1930’s experimented with human and horse urine estrogens, but horse derived Estrogen was more potent, cheaper, and tasted better therefore horse urine estrogen is what us humans animals have been taking all this time. Human derived estrogen at least would have been bio-identical but it was too expensive and bad tasting.
In 1942 Premarin was approved in the US, Even thought published studies warned about its carcinogenic potential
In 1959 a JAMA study proved it effective with no increase in cancer in the 113 patient studies... This study of a whopping 113 patients -Gave Premarin the green light for next 40 years.
In 1966 the Book published, “Feminine Forever” touts estrogen as the “cure for the tragedy of menopause.” The Drug Company pays Robert Wilson 1 million dollars for the book and the glowing endorsement. (In the 1960’s not one baseball player made 1 million dollars) Numerous ads in the 1970’s encouraged patients to take it forever with no risk.
In 1973 the marketing machine decided since it made women feel so good they would study giving it to men; but they had to stop trials because so many men were dying of heart attack and blood clots. (Just like the women did 30 years later when proper studies were done)
In the 1973 Harpers Bazaar article HR “keeps you flirtatiously feminine- a package deal that spruces up your vagina” and the world was hooked. Everyone was doing it, not my mom.
In 1975 NEJM (New England Journal of Medicine) published articles documenting a 14 fold increase in endometrial cancer.
In 1976 a NEJM article linked Hormone Replacement to breast cancer. (This is Pharmaceutical not Bio-identical)
In the late 70’s, Provera added a fake progestin to Premarin attempting to lower the possibility of endometrial cancer.

Prempro came out in 95 -both were in one pill.
In 1985 the Framingham Heart Study documented increased negative Cardio Vascular events
In 1989 a Swedish study showed double the risk of breast cancer.
In 1998 the PEPI trial showed HRT does not prevent MI, as was advertized and an increased risk of 2nd MI was noted in patients.
In 2000 the WHI (Woman’s Health Initiative) was running –scientists gave women an out; the doctors running the study gave participants a chance to drop out of the study because they noted a marked increase in Heart Attack rate.
Still sales approach $2 billion with Lauren Hutton as spokes person.
In 2002 the WHI published the results showing,
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a 26% increase in Breast Cancer
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a 29% increase in Heart Attack
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a 41% increase in Stroke
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a 200% increase in all Blood Clots
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No improvement in overall quality of life
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Increased risk of Alzheimer’s Dementia
Without Prempro on the market, annually we would save
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8,000 cases breast cancer,
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7,000 Cardiac Events,
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8,000 Pulmonary Emboli
Some studies indicate that the duration of exposure is more a factor than dose in producing the adverse events.
The Million Women Study done in the UK showed-
The (RR) Relative Risk of 1.3 for Breast Cancer in women who ever used Pharmaceutical Estrogen replacement.
The RR of 2.0 (even higher) for Breast Cancer if a woman ever used Pharmaceutical Estrogen plus a Progestogen.
Again the risk increased with the duration of use.
In 2003 the company acknowledged the health hazards associated with their Drugs and Wyeth then pushed the use of “low dose” Prempro;
They claimed “Prescribe with Confidence”, however no studies were done and no proof was given of any added safety; they gave the illusion that “low dose” was safer;
Please listen to me, the facts are, the low dose pills are still a gross overdose of an unsafe substance. They may work on your symptoms but so do the natural bio-identical replacement therapies the more informed doctors use...
Val Manocchio MD
American Physicians Wellness Center
Doctors Best Weight Loss Center
(954) 252-5454 / fax (954) 252-5415